Utility of Peanut Component Testing in Children with Peanut Allergy

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Inadvertent exposures in children with peanut allergy.

OBJECTIVES To determine the annual incidence, characterize the severity and management, and identify predictors of accidental exposure among a cohort of children with peanut allergy. METHODS From 2004 to November 2009, parents of Canadian children with a physician-confirmed peanut allergy completed entry and follow-up questionnaires about accidental exposures over the preceding year. Logistic...

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BACKGROUND Studies suggest that siblings of children with peanut allergy (PNA) have a higher prevalence of PNA than the general population. OBJECTIVES The Canadian Peanut Allergy Registry was used to assess the percentage of siblings of registered index PNA children who were 1) never exposed to peanut or 2) reportedly diagnosed with PNA by a physician without either a history of allergic reac...

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BACKGROUND Filaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is associated with peanut allergy, and peanut allergen in household dust correlates with household peanut consumption. OBJECTIVE We sought to determine whether environmental peanut exposure increases the odds of peanut allergy and whether FLG muta...

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Accidental exposure (AE) to peanut in a large cohort of Canadian children with peanut allergy

Background We have previously estimated that the annual rate of accidental exposure (AE) to peanut in a Canadian cohort of 1411 children with peanut allergy, followed for 2227 patient-years, was 11.9% [1]. The cohort has increased to 1825 children, with 4134 patient-years of follow-up, and we determined the incidence of AE in this expanded cohort and described the severity, management, and loca...

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Accidental exposures to peanut in a large cohort of Canadian children with peanut allergy

BACKGROUND We previously estimated that the annual rate of accidental exposure to peanut in 1411 children with peanut allergy, followed for 2227 patient-years, was 11.9% (95% CI, 10.6, 13.5). This cohort has increased to 1941 children, contributing 4589 patient-years, and we determined the annual incidence of accidental exposure, described the severity, management, location, and identified asso...

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ژورنال

عنوان ژورنال: Journal of Allergy and Clinical Immunology

سال: 2018

ISSN: 0091-6749

DOI: 10.1016/j.jaci.2017.12.806